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Consequently, FDAs conclusion that the quality system does not adequately ensure data accuracy and integrity is consistent with the fundamental principle that data integrity is a system responsibility, not a post hoc justification exercise

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In vitro studies confirm that linagliptin suppresses the proliferation of several tumor cell lines, including colorectal cancer HCT116, breast cancer MCF-7, and liver cancer HepG2, via mechanisms that involve cell cycle arrest and apoptosis induction [96]

Managing psoriasis often requires a combination of treatments, including topical creams, oral medications, and sometimes biologics, which are drugs made from living organisms that target specific parts of the immune system

[104] Dose reduction or treatment discontinuation may be necessary if dizziness persists or interferes with daily activities

We summarised the current evidence and available recommendations from the ASA and ESAIC to support clinicians in the perioperative management of patients receiving SGLT2 inhibitors, GLP-1RAs and related therapies (Table 2)