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Description

Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: a 52-week, open-label, phase IV study

Methodology Study design This study is a systematic review and meta-analysis of cardiovascular outcome trials (CVOTs) evaluating the long-term safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in populations at high cardiovascular risk

10.1038/s41419-017-0217-y [DOI] [PMC free article] [PubMed] [Google Scholar] 47.Gudbergsen H, Henriksen M, Waehrens EE, Overgaard A, Bliddal H, Christensen R, Boesen MP, Knop FKK, Astrup A, Rasmussen MU, Bartholdy C, Daugaard C, Bartels EM, Ellegaard K, Heitmann BL, Kristensen LE (2019) Effect of liraglutide on body weight and pain in patients with overweight and knee osteoarthritis: protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial

Metabolic optimization reduces pancreatic stress

Type 2 diabetes (Phase 2, randomized controlled trial): a separate randomized Phase 2 trial published in The Lancet documented strong glycemic control in type 2 diabetes