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In the Phase 2 obesity trial published in NEJM in 2023, retatrutide at the 12 mg weekly dose produced a mean placebo-adjusted body weight reduction of 22.1 percentage points (22.1% (24.2% arm) mean absolute reduction on the retatrutide arm) at 48 weeks (Jastreboff et al., NEJM, 2023)
Telehealth company Hims & Hers dropped its plan to offer a knockoff version of the weight-loss pill Wegovy two days after it announced the new drug and one day after the Food and Drug Administration threatened to restrict access to the ingredients needed to copy popular weight-loss medications
While a single instance may only cause temporary digestive upset, it is important to have a provider monitor your symptoms
Research is advancing to evaluate retatrutides comparative efficacy, pharmacological profile, and positioning relative to other emerging options
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