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Akkermansia Muciniphila : Promising results for insulin sensitivity Akkermansia Muciniphila As for Akkermansia Muciniphila , a bacterium claimed by trending supplement brand Pendulum to increase GLP-1 production, he says, Its a pretty promising microbe when it comes to insulin sensitivity, but Ive not seen any human clinical data about Akkermansia, GLP-1 production and weight loss. On its website, the company (which includes actress Halle Berry among its investors) links to animal research showing that Akkermansia Muciniphila increased GLP-1 production in mice on a high-fat diet

( 10.1056/NEJMoa2032183) [DOI] [PubMed] [Google Scholar] 81.Gether IM, Nexe-Larsen C, Knop FK

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Understanding your genetic predispositions in GLP-1 and glucose-sensing pathways can help you and your provider make data-informed decisions about compounded GLP-1 therapies (semaglutide, tirzepatide) versus lifestyle interventions, or whether a combination approach is most suitable for your metabolic health goals