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The initial models were fitted into the EM density map using the UCSF Chimera 1.17.3 23,24 , followed by interactive rounds of manual adjustment and automated refinement in COOT 0.9.8.92 25 and Phenix 1.21 26 , respectively

Role of GLP-1R biased signaling We next investigated further the agonist-specific factors that might explain the marked differences in trafficking and secretion highlighted above

As insulin levels normalize and drop from previously elevated states, IGF-1 levels may also decline

Tirzepatide's early spikes reflect the Weber effect (elevated reporting in the first 1-2 years post-approval)

Mechanisms of diabetes improvement following bariatric/metabolic surgery