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Statins depleted these Clostridium bacteria, reducing the microbiomes ability to produce UDCA
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Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study

Extra body fat can cause the body to produce more estrogen and less testosterone, throwing off the balance of key reproductive hormones
The weight loss associated with metformin often plateaus because the medication does not activate GLP-1 receptors or suppress hunger hormones like peptide YY and cholecystokinin

Clinical trials demonstrate a clear difference in how these two drug classes affect body weight
