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The diversity in clinical presentations of PCOS is likely a reflection of different pathogenic mechanisms, and has implications not only for timely diagnosis, but also in terms of prognosis, molecular stratification and therapeutic handling of cases

Several groups have designed monomeric dual and triple agonists based on the interactions of GLP-1 with glucagon 54,55,56 and/or GIP 57,58,59

Most are retaining coverage for GLP-1s prescribed to treat Type 2 diabetes meaning Ozempic and Mounjaro used for blood sugar control

Always inform your healthcare provider of all medications, supplements, and over-the-counter products you use

Approximately 95% of BAs are recycled via the hepatic circulation, controlled by fibroblast growth factor 15 and farnesoid X receptor (FXR) ( Figure 1 ) (Shin et al., 2013)
