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Pancreatitis, though rare, has been reported with GLP-1 receptor agonists including tirzepatide

While some of this variation in results is likely attributable to the inherent variability of results between trials, some variation may be attributable to the slight differences in the patient populations between trials, where patients receiving tirzepatide in SURMOUNT-5 had a higher average waist circumference and body weight at baseline (mean [standard deviation (SD)] waist circumference 117.7 [16.1]

If fatigue is significantly impacting your quality of life, your provider can help you explore alternative dosing strategies, add supportive supplements, or discuss whether tirzepatide remains the best choice for you

Sensitivity analyses in the BMI 30 kg/m population yield consistent results

10.1038/s41591-023-02597-w

Zeptide is a prefilled syringe containing Tirzepatide, a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist