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While initial studies indicate it may offer superior weight loss benefits, the long-term safety data are still developing

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Wilding et al., "Once-Weekly Semaglutide in Adults with Overweight or Obesity," NEJM 384:989-1002 (2021)

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Furthermore, PC1/3 colocalization with glucagon was elevated in liraglutide-treated WT mice compared with that in liraglutide-treated KO mice (Figure 1, D and E

Effects of bariatric surgery on mortality in Swedish obese subjects