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In conclusion, it is essential to strategically use both GLP-1RA and SGLT2i for cardiovascular prevention in ASCVD patients with type 2 diabetes by targeting HbA1c levels and achieving blood pressure control (Fig

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While this can help with weight loss as patients are shifting to a lower calorie intake, for some people this calorie deficit can also cause fatigue
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However, the half-life of natural GLP-1 is very short, lasting only 1-2 minutes in the bloodstream