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Despite some progress in bringing this strategy to the clinical stage, to date most active targeting is performed by ligands or antibodies recognizing the extracellular orthosteric site of the target receptor

It sits well under the ~500 Da Lipinski cutoff for good oral absorption, so absorption is built into the chemistry

But the weight loss story isn't the most interesting thing about them

Results of the study Higher levels of insulin and C-peptide As expected, obese subjects had higher levels of insulin and C-peptide before the intervention, demonstrating a pattern of low-grade inflammation and resistance to this hormone

Semaglutide was also situated among emerging latestage therapies, including resmetirom, a thyroid hormone receptor agonist with demonstrated antifibrotic and antisteatohepatitic activity

That could help reduce habits like overeating or smoking by calming brain activity