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The global health body in its 24th Model List of Essential Medicines, under the has enlisted Semaglutidea blockbuster GLP-1 molecule along with its other alternatives including Dulaglutide, Liraglutide and Tirzepatide

In further support of a possibly limited role of native GLP1 in the control of ad libitum food intake, a number of studies have shown that GLP1producing PPG neurons are far less responsive to moderate food intake or gastric distension than neighbouring catecholaminergic neurons in the lower brainstem (Kreisler et al., 2014)

However, to our knowledge, there have been no research studies to investigate the effects of Tirzepatide on alcohol consumption

When semaglutide binds to GLP-1 receptors in the hypothalamus and mesolimbic dopamine system, it may reduce the reinforcing effects of smoking and lower the intensity of cravings

They are also looking at various mouse models of inflammation, including heart disease, atherosclerosis, and liver and kidney inflammation, to establish whether the beneficial effects of GLP-1 in each case are indeed mediated through the brain

In this episode, we unpack whats driving the FDAs increased enforcement and why these shutdowns could signal a broader shift in the compounded medication market