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Retatrutide is an investigational triple-receptor agonist studied for its activity on GLP-1, GIP, and glucagon receptorskey pathways involved in appetite signaling, glucose regulation, energy balance, and metabolic adaptation

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China had 947 GLP-1 clinical trials in 2025

GLP-1RAs show modest SBP reductions (1.85.1 mmHg) and minimal DBP effects (~0.5 mmHg), though tirzepatide shows greater efficacy (~10.6 mmHg) in select populations