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Specifically in colon cancer and prostate cancer, exendin-4 increased intracellular cAMP levels while inhibiting glycogen synthase kinase 3 and ERK-MAPK activation, leading to an increase in apoptosis [93]

Diabetes promotes the progression of MASLD to steatohepatitis, cirrhosis, and hepatocellular carcinoma

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Overexpression of miR-132 or miR-212 increases glucose and GLP-1-stimulated insulin secretion [170]

GLP-1 drugs may target an earlier step in the drug attachment, addiction, and relapse cycle

For example, phentermine can cause a rapid or irregular heart rate, high blood pressure, headache, and insomnia