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Significant effects of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

doi: 10.7759/cureus.51788

CYP2D6 different genotypes have been associated with four predicted phenotypes based on their CYP2D6 enzymatic function: poor (PM), intermediate (IM), extensive (EM) and ultra-rapid (UM) metabolizers ( Table 2 )

Meanwhile, patients on 1 mg, 1.7 mg, 2 mg and 2.4 mg injectable semaglutide had a median weight loss of 4.5%, 6%, 5.9% and 10%, respectively