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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Stang A

The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

2 Among the people who stayed on the medication and reached the full dose, average weight loss reached 16.6%

Case reports with a small number of patients are not generalizable, though they do suggest that some women may experience a normal pregnancy if they transition off a GLP-1 medication during the first trimester

What PCOS Patients Should Know Before Starting Tirzepatide Tirzepatide is not FDA-approved specifically for PCOS, but mounting clinical evidence and real-world data support its use off-label in this population

95% CI, 2.1-3.7)