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Research Evidence Comparison# Retatrutide Research# Phase 1 : First-in-human study established safety and pharmacokinetics Phase 2 (n=338) : Published in NEJM (2023), demonstrated dose-dependent weight loss up to 24.2% at 48 weeks with 12 mg dose

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'European regulator investigates Ozempic, Wegovy maker on thyroid cancer risk', reported one headline

Weight regain typically begins within 1-3 months of discontinuation, with most patients regaining 50-75% of their lost weight within one year

The known microvascular diseases and disorders encompass a broad spectrum of conditions affecting small blood vessels (arterioles, capillaries, and venules) across multiple organ systems

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