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But there is another layer

Antibody-Mediated Rejection (AMR): Mediated by B-cells producing donor-specific antibodies (DSAs) that attack the graft endothelium

(2025) used chemogenetics to selectively activate GLP-1-expressing neurons in the nucleus tractus solitarius (NTS) while recording dopamine release in the nucleus accumbens

doi: 10.1038/s42255-020-00327-x 16 ZhaoXWangMWenZLuZCuiLFuCet al

Additionally, it is used to reduce the risk of major cardiovascular events in patients with type 2 diabetes and existing heart disease

Another example, reduction in amyloid beta plaques, can predict improvement of cognitive function for patients with Alzheimers disease