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Trenkwalder, C

Peripheral administrations of native GLP-1 that mimic its release from the gastrointestinal tract under physiologic conditions decrease food intake in a dose-dependent manner (5759)

GLP-1s are a powerful tool, but they're never a standalone solution

GLP-1RA Mechanism of Action GLP-1 (glucagon-like peptide-1) is a hormone secreted by the intestinal tract during feeding, which enhances insulin secretion and inhibits glucagon secretion in a glucose concentration-dependent manner, and delays gastric emptying to reduce the amount of food eaten through central appetite suppression

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They work by binding to GLP-1 receptors in the body