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If genuine tachyphylaxis is confirmed, strategies include dose escalation to the next tier, brief treatment breaks of 2 to 4 weeks to allow receptor resensitization, or switching to alternative GLP-1 agonists like semaglutide to provide different receptor activation patterns

Likewise, first- and second-phase insulin secretion and insulin sensitivity were increased, while postprandial plasma glucose concentrations and plasma glucagon concentrations were lowered

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