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Moreover, a counterintuitive reduction in N-terminal pro B-type natriuretic peptide concentrations on top of weight reduction has been shown in both STEP HFpEF trials, indicating potential direct cardiac effects of the therapies

Dipeptidyl peptidase-4 (DPP-4) inhibitors were first investigated in 2002 for the management of hyperglycemia in patients with type 2 diabetes

Lancet 398 , 18111824 (2021) H.J.L

The difference, increasingly, comes down to which medication class a person chooses, how that medication interacts with their specific biology, and whether the treatment timeline matches their actual goals

Finally, there was either no heterogeneity or very little heterogeneity in our meta-analysis

Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial