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[1] [2] The physiologic role of GLP-1 includes stimulating glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

One-year results of the global phase 2b randomized placebo-controlled ARREST trial of aramchol, a stearoyl CoA desaturase inhibitor, in patients with NASH [abstract]

Mechanism: Most are pure GLP-1 receptor agonists, but tirzepatide is unique in targeting both GLP-1 and GIP receptors