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The primary risks include bile duct stones or obstruction, compounded gastrointestinal side effects (nausea, diarrhoea), and pancreatitis

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, et al

Additionally, weight loss triggers compensatory metabolic changesyour body reduces energy expenditure and increases hunger hormones like ghrelin while decreasing satiety hormones like leptin

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Why triple agonism produces superior results The synergistic interaction among these three receptors creates metabolic effects that exceed what any single pathway can deliver

Each one is preventable