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This meta-analysis assessed the safety and effectiveness of combinations of SGLT2is+GLP-1RAs with a focus on their cardioprotective effects along with glucose-lowering ability in patients with type 2 diabetes mellitus (T2DM) in a real-world setting

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Semaglutide is an antidiabetic medication indicated for the treatment of type 2 diabetes , as it works by stimulating the production of insulin in the pancreas and decreasing the production of glucagon, which helps reduce blood glucose levels, along with a healthy diet and regular exercise

Clinical trials (ten studies, 419 participants) using doses from 400 mg to 10 g over 21 days to 20 months show consistent reductions in fasting glucose, post-meal glucose, and HbA1c. In diabetic animal studies, gymnema increased proglucagon gene expression (a precursor for GLP-1) and insulin gene activity, suggesting it may help amplify endogenous GLP-1 production

Discover clinical trial results and which GLP-1 medication may be right for you.

Gymnema sylvestrehas been used traditionally in India for over 2,000 years