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The Basics at a Glance Generic name: Retatrutide (development code: LY3437943) Manufacturer: Eli Lilly and Company Drug class: Triple agonist (GLP-1/GIP/glucagon receptor agonist) Administration: Once-weekly subcutaneous injection Dosing range: 2mg to 12mg weekly (gradual titration over 12+ weeks) Half-life: Approximately 6 days (reaches steady state in 45 weeks) FDA status: Phase 3 clinical trials (TRIUMPH program) Expected approval: 20272028 How Retatrutide Differs from Other GLP-1 Medications To understand retatrutide, it helps to see where it fits in the evolution of GLP-1 class medications

doi: 10.1016/j.atherosclerosis.2015.03.026 8 LeonardiniADOriaRIncalzaMACaccioppoliCBuccheriVACignarelliAet al

[DOI] [PubMed] [Google Scholar] 132.Sumithran P., Russell A.W., Zoungas S

Related Stories Researchers propose simple finger prick test to track metabolic health Study links gut microbes to stronger cancer immunotherapy responses Popular diabetes drugs do not alter the risk of developing a blinding eye condition The hazard ratio (HR) of thyroid cancer in the GLP-1RA group was 1.24 as compared to those prescribed non-GLP-1RA medications

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Supports Healthy Blood Sugar GLP-1 helps the pancreas release insulin when blood sugar rises after eating