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WHO GLP-1 Treatments: The World Health Organization has issued new guidelines endorsing GLP-1 agonists as essential treatments for obesity, highlighting the urgent need for action against the rising global obesity epidemic affecting over one billion people and posing serious health risks.

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A new ligand against the GPCR GLP-1R acts as a positive allosteric modulator, binding both the receptor and the orthosteric ligand, accessing the peptide ligand within the interface between transmembrane domains 1 and 2 of the receptor.

The subcutaneous injection is long acting and is taken once weekly, while the oral tablet is taken once daily

This can potentially be achieved by targeting and skipping specific exons of the Duchenne muscular dystrophy gene to restore the disrupted reading frame and to induce the production of a semi functional dystrophin protein