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The long-term safety of GLP-1s is still being established, but emerging research has begun to highlight several areas of concern

Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)

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This dual action places it between semaglutide and Retatrutide in both efficacy and side effect profile

La Vignera S, Condorelli RA, Vicari E, DAgata R, Calogero AE

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