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Description
Interestingly, obesity, for whose treatment GLP-1RAs are approved and validated 1,214 , is not classified under mental and behavioral disorders, and in some countries, such as the United Kingdom, it is not even formally recognized as a disease 246

You inject it under the skin (subcutaneously) in your abdomen, thigh, or upper arm

Semaglutide presents a pronounced weight-lowering effect, mediated by direct GLP-1 stimulation of the anorexigenic (satiety inducers) proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) neurons along with indirect inhibition of orexigenic neurons (appetite inducers) neuropeptide Y (NPY) and agouti-related peptide (AgRP), located in the arcuate nucleus (ARC) in the hypothalamus, which is vital in the regulation of appetite and energy balance [114,115,116]

Patients often experience enhanced tolerability through the gradual therapeutic introduction, with a notably reduced incidence of gastrointestinal side effects

Busque atencin urgente si experimenta dolor abdominal severo (especialmente en la parte superior que se irradia a la espalda), vmitos persistentes, sangre en heces, distensin severa sin evacuaciones o signos de deshidratacin

Results We included 1,647,238 patients who were prescribed a GLP-1 RA between January 2024 and July 2025, with 6,059,445 total GLP-1 RA prescriptions during this period
