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Between 45% and 70% of patients discontinue therapy in the first year, most commonly because of cost, inconsistent insurance coverage or gastrointestinal side effects

However, some individuals prefer to inject semaglutide GLP-1 at specific times that align with their daily routines

For some women, this may be a positive change

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Mechanism of Action Exogenous GLP-1 RA have been more recently considered as a good choice for treating patients with diabetes it works by incretin effect [1] intestinal component accounts for 50%- 70% of the total insulin secreted after an oral glucose load [2]

Both Zepbound (tirzepatide) and Wegovy (semaglutide GLP-1) typically begin to show noticeable effects on appetite and weight within the first month of treatment