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You need steady state to judge whether a dose is adequate

Using the same spot repeatedly causes lipodystrophy, a condition where subcutaneous fat thins or thickens at the injection site, altering absorption kinetics and potentially causing visible skin changes

The consistency across doses suggests this is not simply a downstream effect of weight loss but may represent a direct pharmacological action on inflammatory pathways

Thats the main reason its being studied so closely right now

As with marijuana, alcohol can impact how you respond to anesthesia

Moubarak Supplemental material: Supplemental material for this article is available online