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Research Highlight Published: Osteoarthritis Nature Aging volume 5 , page 11 (2025) Cite this article 846 Accesses 5 Altmetric Metrics details Subjects In this study, the team of researchers report the results of the STEP 9 trial (NCT05064735), a 68-week, multicenter, double-blind, randomized, placebo-controlled trial to evaluate the effectiveness of subcutaneous administration of the glucagon-like peptide 1 receptor agonist semaglutide (2.4 mg) in 407 participants with obesity (body-mass index of 30) who were also clinically diagnosed with moderate knee osteoarthritis and moderate-to-severe pain, from 61 sites across 11 countries

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