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Engs persistence, nurtured by his training under a Nobel laureate who had herself challenged orthodoxy, kept the idea alive long enough for science to catch up

As people increase their dose of the drug, the unpleasant GI effects can get worse before they get better

they may alter the pharmacological doses of GLP-1, thus lowering inactivated DPP-4 kinetics

It was also found that ROS-mediated endoplasmic reticulum (ER) stress in Mller cells upregulates CHOP (C/EBP homologous protein), promoting apoptosis and glial activation in early DR (67, 68)

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12 Effector T cell exclusion Oncogenic signaling pathways within tumor cells frequently contribute to immune evasion by limiting effector T cell infiltration into the TME