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You are not trying to blast the powder apart
So a 12.5% deficit at your starting weight becomes a smaller deficit at a lower weight, even if your eating stays exactly the same
However, persistent or severe vomiting warrants medical review, as dehydration and electrolyte disturbances can occur, potentially leading to acute kidney injury

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2023 NEJM) found semaglutide reduced overall cardiovascular event rates by 20% despite the small HR increase
This makes it important to get enough protein and do light strength exercises during treatment