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Skyrizi (risankizumab) is used for moderate-to-severe plaque psoriasis and active psoriatic arthritis in patients 6 years and older, and Crohn's disease and ulcerative colitis in certain adults

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Phase 2 clinical trials have demonstrated exceptional efficacy for weight reduction, with up to 24.2% weight loss at 48 weeks with the highest doseresults that exceed those typically observed with existing GLP-1 receptor agonists
In mouse studies, boosting BCL6 reversed muscle weakness and shrinkage, hinting at a future where weight-loss shots could be paired with a muscle-preserving therapy.
