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Additionally, both medications cause a delay in gastric emptying, which can result in stomach paralysis (gastroparesis), intestinal blockage (ileus), and other severe gastrointestinal side effects

However, significant weight reboundoften exceeding baselineoccurs in 40-80% of users within one year of discontinuation

Research on the long-term effects of semaglutide is limited Some studies suggest that the medication may be safe for extended periods

The drugs ability to induce weight loss, improve glycemic control, and reduce cardiovascular risk factors likely contributes to better fertility outcomes (higher testosterone, better sperm quality) and improved erectile function in men who have metabolic dysfunction