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doi: 10.1158/0008-5472.CAN-17-0580

Introduction Sustained glycaemic control and weight loss are key targets for people with type 2 diabetes (T2D) [1, 2], with current guidelines recommending a patient-centred approach for treatment selection [1]

Informative on the new anti-obesity GLP-1MK-801 conjugate from @OdgaardJonas @BueKlein and @ClemmensenC Lab Targeting to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity

however, the degree and severity of reported side effects in certain circumstances may have been due to drug purity or dosing issues

What this means for you as a buyer: Sunlight may be worth further review if you're a clinical candidate and the cost of brand-name GLP-1 drugs is prohibitive - which for most people without insurance coverage, it still is

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