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As GLP-1 therapies gained approval for obesity, prescribing began to diffuse beyond endocrinology into primary care, obesity medicine, and digital health platforms

Ongoing care allows patients to keep their weight and metabolic health stable

Interestingly, we also detected a similar association between the other incretin receptor, glucose-dependent insulinotropic polypeptide receptor (GIPR), and endogenous SPHKAP following GIP stimulation of INS-1 832/3 cells stably expressing SNAP/FLAG-hGIPR (Supplementary Fig

To evaluate the incidence of MACE-4 events in patients treated with tirzepatide compared to the control group, a meta-analysis was conducted using data from 7778 patients enrolled in the SURPASS-4 study, SURPASS Clinical Trails Program (which includes 7 randomized clinical trials), and SURMOUNT-1

Second, vomiting showed a clearer dose-dependent increase, rising from 13.0% at 6 mg to 24.0% at 36 mg

Staying hydrated, eating smaller frequent meals, and maintaining consistent injection timing help smooth out these weekly fluctuations