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If necessary, the dose can be further increased to 1 mg once a week after a minimum of four weeks on the 0.5 mg dose

Clinical outcomes of tirzepatide or GLP1 receptor agonists in individuals with type 2 diabetes
Clinical pharmacology of incretin therapies for type 2 diabetes mellitus: implications for treatment

Diabetes Metab Res Rev (2021) 37(1):e3353

While medications approved for the treatment of type 2 diabetes have led to weight loss, they are not approved for off-label use, such as weight loss

Ex vivo human placental transfer of the peptides pramlintide and exenatide (synthetic exendin-4)
