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While norepinephrine seemingly inhibits GLP-1 secretion via its action on -adrenergic receptors, its secretion is stimulated by isoproterenol, and this effect can be blocked by co-infusion of the -adrenergic receptor antagonist propanolol [337]

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The treatment-regimen estimand results at 68 weeks showed -20.0% body weight change (approximately 50.5 pounds) in the 9 mg group and -23.7% (approximately 60 pounds) in the 12 mg group

Yono et al

Glucagon pushes the level up to maintain the balance