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The added impact of GLP-1s The rapidly changing GLP-1 landscape is only compounding this challenge

Ein anderer Ansatz zur Entwicklung langwirkender GLP-1-RA war die Anbindung leicht modifizierter GLP-1-Molekle an groe Eiweimolekle (Immunglobulin-Fragmente im Falle von Dulaglutid und Efpeglenatid, Albumin im Falle von Albiglutid) (23, 24)

J Biol Chem 267(11):74027405 Schirra J, Sturm K, Leicht P, Arnold R, Goke B, Katschinski M (1998) Exendin(939)amide is an antagonist of glucagon-like peptide-1(736)amide in humans

GLP-1 receptor agonists slow how quickly food leaves the stomach (gastric emptying)

Individual answers may be required for various compounds in the class of incretin mimetic drugs

J Clin Med 2024