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The sample size in both ISAs provides at least 90% power to demonstrate superiority of tirzepatide to placebo for the mean percent change from baseline in AHI at a 2-sided alpha level of 0.05, assuming 50% improvement compared with placebo, with a common standard deviation of 50%, and up to 25% of participants discontinuing the study drug in each arm

GLP-1 medications short for glucagon-like peptide-1 receptor agonists are a class of drugs that mimic the effects of a natural hormone called GLP-1

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Additionally, the understanding of the mechanisms of GCGR agonists is complicated by its potential activation of the GLP-1R (Neumann et al