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Underlining the role of PCSK2 in liberation of glucagon via proglucagon processing, PCSK2-deficient mice are slightly hypoglycemic upon fasting, have a reduced rise in blood glucose following intraperitoneal glucose administration, display impaired processing of Gcg in the -cells, and develop -cell hyperplasia [154,155]

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En un estudio reciente se demuestra que combinar estos frmacos (agonistas de GLP-1) con ejercicio fsico ayuda a preservar la masa muscular y sea vs el frmaco slo, con el que existe una importante prdida de masa sea (26)