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Lipoylated protein aggregation is associated with the destruction of iron-sulfur cluster proteins, commonly initiated by ROS [54]

Higher concentration of cPTIO could not be used in apoptosis- reversal experiment because of toxicity induced by cPTIO itself

The signing of the Montreal Protocol in 1987 led to a surge in innovation that resulted in the diversification of inhaler technologies with significantly enhanced delivery efficiency, including modern pMDIs, dry powder inhalers, and nebuliser systems

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Furthermore, LDN can influence macrophage polarization, promoting the shift from the pro-inflammatory M1 phenotype (CDR1) towards the restorative M2 phenotype (CDR3), thereby assisting the cell in resolving inflammation and re-entering the repair phase

2023;497 doi: 10.1016/j.tox.2023.153630