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In colorectal cancer, miR-21 is the target phosphatase, and PTEN is a protein which is overexpressed via curcumin, while in non-small cell lung cancer is under-expressed (Zhang et al., 2010)

Include negative controls (e.g., unrelated dermatologic outcomes) and surveillance bias adjustments

Search terms included relevant keywords and controlled vocabulary (e.g., MeSH and Emtree terms) for T2DM, GLP-1 receptor agonists, multi-target agonists, and gastrointestinal outcomes, combined with terms for randomized controlled trials

Reviews in endocrine & metabolic disorders, 15(3), 181187.

The future of metabolic healthcare will be defined not only by stronger molecules, but by stronger evidence-to-market frameworks

By years end, Zepbound may unlock its third indication heart failure with preserved ejection fraction (HFpEF ) which will provide new growth for its performance