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Description
Structured recalibration when standard initiation doses are not tolerated: If a patient meets treatment criteria but cannot tolerate the lowest studied initiation level, a lower starting exposure under clinical monitoring may allow incremental receptor engagement while tolerance improves

With the exception of exenatide, there is an initial dose escalation phase, with clinicians starting treatment at the lowest approved dose and escalating at intervals thereafter, mainly to improve tolerance

In this scenario, preventing excess glucagon secretion helps lower blood sugar levels

doi: 10.1212/WNL.41.2_Part_1.202, PMID: [DOI] [PubMed] [Google Scholar] 23.Pappata S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, et al
Your metabolism needs multiple signals activated to shift the needle

Speak to your healthcare provider if you have specific medical or nutrition questions
