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Source: STEP 1 trial data (Wilding et al., NEJM 2021) Tip: If side effects are severe at a new dose, your prescriber may hold the current level for an extra 4 weeks or drop back to the previous dose temporarily

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

[DOI] [PubMed] [Google Scholar] 14

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