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This review summarizes some of the clinical data on GLP-1 RA (Table 3), with some exciting results

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Relevant resources include: ClinicalTrials.gov lists ongoing and completed trials globally, including Phase 3 studies of LY3437943 EU Clinical Trials Register covers trials conducted within the European Economic Area NIHR Be Part of Research (www.bepartofresearch.nihr.ac.uk) the UK-facing resource for patients wishing to find and enquire about clinical trials in the United Kingdom Retatrutide's Current Status in the UK and MHRA Approval Process Retatrutide is unlicensed in the UK as of mid-2025 and is only available within authorised clinical trials

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Together, these studies suggest that what the GLP-1 does for food-related noise, it may also do in other domains, such as drug addiction

Preliminary data from retatrutide trials suggest that a proportion of weight lost may include lean mass, though the clinical significance of this in otherwise healthy individuals remains under investigation