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It is possible that activation of glucagon receptors drives further weight reduction

Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy

Further delineation of the mechanisms underlying alpha-cell GLP-1 production is needed to fully characterize this intra-islet paracrine feedback loop

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MSDC-0602K has shown substantial decreases in glucose, insulin, liver enzymes, and the non-alcoholic fatty liver disease activity score (NAS) in patients with biopsy-confirmed MASH and fibrosis (F1-F3) with minimal side effects, 21 prompting a phase 3 study to assess the benefits of MSDC-0602K on glycemic control and cardiovascular outcomes in patients with pre-T2D or T2D and MASLD/MASH (NCT03970031)