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The combination also increases the risk of nausea and can further stress the GI tract during the window when side effects are already most likely

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Tirzepatide (Mounjaro), the dual GIP/GLP-1 receptor agonist, is licensed by the MHRA for the treatment of type 2 diabetes

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For example, participants who completed a 36-week treatment of tirzepatide, a commercially available GLP-1 RA, regained almost half the weight previously lost after switching to a placebo

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