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Many people also notice early wins, like fewer food-related thoughts or cravings

2009 in PNAS (PMC2667044) showed stress suppressed preproglucagon (PPG) mRNA in rat NTS neurons within 30 minutes via a glucocorticoid-dependent mechanism

Second, with any short-term agent, durability is the weak point short-term weight loss is common, but the majority of patients regain weight over the following years unless the underlying behavior and physiology are addressed

The Journal of Pharmacology and Experimental Therapeutics, 314, 11951201

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